The Post Office Hotel was built in 1889, for Messrs Hanley and Williams of Maryborough, to a design of Victor Emmanuel Carandini, a Brisbane architect. Situated right at the top end of Wharf Street, the hotel is near the Portside Heritage area and the central business district.
The early post-supported verandah, which lined the two principal facades of the building, was replaced with a cantilevered version. This was in line with a general movement in Maryborough to modernise the central business area in the 1930s by replacing all post-supported awnings with cantilevered alternatives.